In the present research work floating matrix tablet formulation of Cefpodoxime Proxetil was prepared by using different polymers. Initially analytical method development was done for the drug molecule. An absorption maximum was determined based on the calibration curve developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of Sodium CMC, Methyl Cellulose, Carrageenan as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations, The formulation prepared with Sodium CMC released the drug up to 24 hrs (F2= 99.78%). The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release.