Formulation and Evaluation of Atorvastatin Floating Tablet

International Journal of Novel Trends in Pharmaceutical Sciences,2017,7,5,130-138.
Published:October 2017
Type:Research Article
Authors:
Author(s) affiliations:

Rina Parveen H*, Samiyathuneesa.P, Shana Nazrin C.P, Siva. P
Department of Pharmaceutics, Grace College of Pharmacy, Kodunthirapully, Palakkad 678004, Kerala, India.

Abstract:

The aim of the present study was to develop floating matrix tablets of Atorvastatin to achieve prolong gastric residence time, leading to an increase in drug bioavailability and patient compliance. Floating tablets were prepared by wet granulation technique. The granules prepared and characterized for Bulk density, Tapped density, Carr’s index, Hausner’s ratio and Angle of repose. Developed formulations were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro drug release, floating lag time and floating buoyancy. All the formulations exhibited acceptable physical properties and the best formulation (F3) was selected based on in vitro characteristics. The most successful formulation F3 contains Atorvastatin (40mg), Methocel K100M (70mg), sodium bicarbonate (130mg), citric acid(10mg), PVPK30 (50mg), talc (30mg) and lactose (170mg). These formulations need 50 sec to become buoyant, appropriate hardness (3.5kg/cm2) and percentage cumulative release of 4.35%.

Downloads: 
In-page image(s): 

Angle of repose of Atorvastatin granules