Synthesis, Characterization and Biological Evaluation of Heterocyclic Derivatives

International Journal of Novel Trends in Pharmaceutical Sciences,2017,7,4,124-129.
Published:August 2017
Type:Research Article
Authors:
Author(s) affiliations:

Kavitha K1*, Rajavelu R2, Sivakumar T2, Vijayakumar B1
1Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala- 678004, India.
2Nandha College of Pharmacy and Research Institute, Koorapalayam Pirivu, Erode, Tamil Nadu 638052, India

Abstract:

In the present study, a series of novel quinazolinone derivatives by the reaction of an anthranillic acid with benzoyl chloride to form the intermediate product of benzoxacin 4 one which is treated with hydrazine hydrate and condensed by 4 chloro- benzaldehyde, 4 chloro- phenyl amino thiadiazole, ketone derivatives, mercaptoacetic acid, and THF. The chemical structures of the synthesized compounds were confirmed by means of IR, H1-NMR and mass spectroscopy. These compounds were screened for anti-inflammatory (Carrageen-Induced Paw Edema), analgesic activity (Eddy’s hot plate method) and anti-bacterial activity (Plate Hole Diffusion Method) against gram +ve and gram –ve bacteria. Compound QD-A and QD-C had given good anti-inflammatory and compound QD-A and QD- B analgesic activity compare to standard. All the synthesized compounds exhibit good antibacterial activity. Compounds QD-A and, QD-B, exhibited good antibacterial activity on Escherichia coli and Bacillus subtilis.

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Synthesis, characterization and biological evaluation of heterocyclic derivatives