Transdermal patch of curcumin (curcuma longa) was prepared by using two different grades of hydroxy propyl methyl cellulose and other additives. Curcumin an ayurvedic herbal drug used as an anti arthritic agent. Dimethyl sulfoxides (DMSO), polyvinyl alcohol (PVA) were used as permeation enhancers and polyethylene glycol (400% w/v) was used as plasticizer. The prepared films exhibited satisfactory physiochemical characters such as percentage moisture absorption, percentage moisture loss, thickness & weight of drug content. In vitro drug release release. The present work showed that drug of ayurvedic origin can be utilized in a better form with was determined by semi permeable membrane using Franz diffusion cell]. The films formed using HPMC were thin, flexible and smooth and these patch with permeation enhancer showed maximum enhanced efficacy for incorporation into modern dosage forms. The sustained release of curcumin from transdermal patches can minimize the frequent administration of conventional curcumin dosage forms.