Homology Modeling and Domain Analysis Studies on (CHRNA5) Lung Cancer Protein using Bioinformatics Methods

International Journal of Novel Trends in Pharmaceutical Sciences,2016,6,3,51-54.
Published:June 2016
Type:Research Article
Authors:
Author(s) affiliations:

Hepzibah. W1*, John William S1 and Balaji. M2

1P.G and Research Department of Advanced Zoology and Biotechnology, (SECNARM), Loyola College, Chennai-600034, Tamil Nadu, India.

2Managing Director, Akshaya Computational Medicine Pvt, Ltd., Chennai-600005, Tamil Nadu, India.

Abstract:

Globally, lung cancer is the most common cancer among men in terms of both incidence and mortality and among women has the third highest incidence, and is second after breast cancer in mortality. The aim of the research work is to find out the potential mutation gene involved in human lung cancer. Based on literature studies, we identified the potential gene candidate for drug docking studies. Our protein modeling results show the molecular structural regions present in CHRNA5 protein. We also identified the potential domain regions of the protein sequences of the CHRNA5 protein. The results clearly elucidate that the modeled protein candidate acts as a very good candidate for introducing the various novel chemical molecules.

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Domain prediction (DLM-SVM server)