Tribulus terrestris (Nerunji mullu), Butea monosperma (Parasa pattai) and Chicorium intybus (Kasini keerai) are the traditional herbal medicines used in Siddha and Ayurvedic system. They are analyzed for their creatinine reducing activity along with other related parameters. All the three plants showed high potent phytochemicals such as Alkaloids, Phenolics, and Flavonoids, the chemicals known for antimicrobial, antioxidant, immune modulatory activity, and anticancer activities. Metabolism correction is the common features of chemicals having antioxidant activity. Most of them including others responsible for nephron protective activity by controlling creatinine level from deleterious level to non-dangerous level. To identify the effectiveness of Tribulus terrestris, Butea monosperma and Chicorium intybus on Creatinine reducing activity in KMnO4 induced rats where Simvastatin used as a positive standard by following hematological, biochemical and histopathological analysis with the objective to use these natural agents with no side effects for Creatinine reducing activity instead of chemicals which has got more side effects and costlier.