A Review on Prodrugs

International Journal of Novel Trends in Pharmaceutical Sciences,2016,6,1,1-5.
Published:February 2016
Type:Review Article
Authors:
Author(s) affiliations:

L. Karpagavalli*, M. Vigneshwar, M. Monisha, M. Prabavathi, Podili Prasanth, K. Zairudeen

Department of Pharmaceutics, Jaya College of Paramedical Sciences, College of Pharmacy, Thiruninravur -602024, Tamilnadu, India.

Abstract:

A Prodrug is a combination of active drug with an inactive or inert material which will undergo biotransformation in vivo to yield the active drug to produce pharmacological action. The prodrug has certain characters which it should undergo or obey to be an ideal prodrug. The wide range of application of prodrug shows the importance of prodrug in modern medicine. Some types of prodrugs like photosensitive prodrug therapy, ADAPT and ADEPT are now a developing concept which sooner will emerge as major part in one of the newer trends of medicine. Few limitations of the prodrugs are seen which should be minimised and their use should be increased.

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Activation of a photosensitive drug & its possible modes of action