Insilico Gene Expression and Protein Structure a Comparative Study on Polycystic Ovarian Syndrome and Ovarian Cancer in Human Beings using Bioinformatics

International Journal of Novel Trends in Pharmaceutical Sciences,2015,5,3,74-83.
Published:June 2015
Type:Research Article
Authors:
Author(s) affiliations:

Surya Prabha. U1*, Sakila. L 2 and Balaji. M 3

1Post Graduate and Research Department of Zoology, Ethiraj College for Women, Chennai, Tamilnadu, India.

2Associate Professor, Post Graduate and Research Department of Zoology, Ethiraj College for Women, Chennai, Tamilnadu, India.

3Senior Bioinformatician- Akshaya Computational Medicine Pvt, Ltd., Chennai, Tamilnadu, India.

Abstract:

Ovarian cancer is a cancer that begins in an ovary. It results in abnormal cells that have the ability to invade or spread to other parts of the body. Polycystic ovary syndrome (PCOS) is a set of symptoms due to a hormone imbalance in women. PCOS is due to a combination of genetic and environmental factors. The aim of our present research investigation is to focus on gene expression and molecular structural relationships between Polycystic Ovarian Syndrome and Ovarian Cancer using advanced Insilico protocols. We identify the protein targets YAP1 (Yes Associated Protein 1) and FILIPIL (Filamin A Interacting Protein 1 Like) which are potential drug target for Polycystic Ovarian Syndrome and Ovarian Cancer. The three dimensional structure comparison studies clearly show that the two proteins target have similar sequence and structure. The identified protein target and Insilico gene expression studies would be useful in the field of clinical oncology

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Protein structure comparison via ipba