RP-HPLC Method Development and Validation of Valizodone in Pure and Tablet Dosage Form

International Journal of Novel Trends in Pharmaceutical Sciences,2015,5,2,25-26.
Published:April 2015
Type:Research Article
Authors:
Author(s) affiliations:

Thangabalan B, Lakshmi Narusu R*, Syedali Fathima SK and Manohar Babu S

SIMS College of Pharmacy, Mangaldas Nagar, Guntur-522 001, Andhra Pradesh, India.

Abstract:

A simple, precise, rapid, accurate and economic reverse phase high performance liquid chromatographic method has been developed for the estimation ofValizodone in tablet dosage form. The separation was achieved by using octadecylsilane column (C18) and acetonitrile : water in proportion of 60:40 v/v as mobile phase, at a flow rate of 1.0 ml/min. The detection was carried out at 240 nm. The retention time of Valizodone was found to be 4.3 min. The limit of detection and limit of quantitation were found to be 0.11 μg/ml and 0.33 μg/ml respectively. The accuracy and reliability of the proposed method was carried out by evaluating various validation parameters like linearity, precision, accuracy and specificity according to ICH guidelines

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Standard chromatogram of Vilazodone