A Review on Hyperlipidemia

International Journal of Novel Trends in Pharmaceutical Sciences,2014,4,5,81-92.
Published:October 2018
Type:Review Article
Authors:
Author(s) affiliations:

K. Nirosha1, M. Divya1, S. Vamsi1, Mohemmed Sadiq2

1Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati, A.Ranganpet, Andhra Pradesh-517102, India.

2Krishna Teja Pharmacy College, Chadalawada Nagar, Renigunta Road, Renigunta Road, Tirupati – 517501, India.

Abstract:

Hypelipidemia is a condition of elevated lipid level in blood. Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis related conditions like coronary heart disease (CHD), ischemic cerebrovascular disease, peripheral vascular disease and pancreatitis1-2. The increase in lipids like low density lipoproteins (LDL), cholesterol (esters derivatives) and triglycerides are mainly responsible for this condition. These lipids are associated with blood plasma proteins and remain in the dissolved state in the blood. The primary reason for hyperlipidemia is defect in lipid metabolism which is caused by the defect in lipoprotein lipase activity or the absence of the surface Apoprotein C-II. Other causes of hyperlipidemia include various genetic abnormalities and environmental factors.

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Endogenous transport from the liver (VLDL-LDL pathway)