On 21st century, in pharmaceutical field lyophilization has become important subject to ongoing development and its expansion. Lyophilization is common, but cost intensive. In old days process optimization was focused only on drying rather than lyophilization. But lyophilization was more (or) equally important for the process of pharmaceuticals. This review focused on the recent advances and its targets in near future. At first, the principle, steps involved, formulation aspects and importance of lyophilization was explained.