Formulation and Evaluation of Biphasic Delivery System of Aceclofenac Mini-tablets in Hard Gelatin Capsules

International Journal of Novel Trends in Pharmaceutical Sciences,2013,3,2,39-45.
Published:April 2013
Type:Research Article
Authors:
Author(s) affiliations:

D. Karthikeyan*, A. Vijayalaxmi , C. Santhosh Kumar

Department of Pharmaceutics, Srikrupa Institute of Pharmaceutical Sciences, (Affiliated to Osmania University), Velikatta, Kondapak, Siddipet, Medak-502277, Andhra Pradesh, India.

Abstract:

Investigated the feasibility of formulating a biphasic delivery system using mini-tablets in hard gelatin capsules delivering drug with a variety of release profiles. Aceclofenac (NSAID analgesic) were chosen as model drug. Immediate release minitablets (IRMT) were manufactured by direct compression using microcrystalline cellulose and cross carmellose as a superdisintegrant, each mini-tablet containing approximately 25 mg Aceclofenac (AFC). Sustained release mini-tablets (SRMT) were formulated using various ratios of HPMC K4M and HPMC K100M. Capsules were filled with individual mini-tablets to deliver 100 mg of AFC. The IR and SRMT were combined in the capsule designed to provide a pulsatile or multi-phase delivery of drug as immediate and sustained dissolution release profiles. Capsules containing AFC immediate release mini-tabs were shown to release nearly 100% of the drug within 60 mins. Capsules containing SRMT released 98 % of AFC over 12 hrs. The feasibility of delivering a drug in biphasic immediate sustained release manner was reputable by combining mini-tablets in a hard gelatin capsule

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Encapsulated mini-tablet