The anticonvulsant activity of chloroform and Methanol extract of Peperomia tetraphylla was investigated by studying the effects on seizures induced by maximal electroshock (MES) and Pentylenetetrazole (PTZ) methods in Rats. Peperomia tetraphylla with dose of 250&500 mg/kg show significant activity reduced the tonic extensor convulsion induced by maximum electroshockinduced convulsions comparison with the reference standard phenytoin 25 mg/kg. It significantly decreased the onset of convulsion in seizure induced by pentylenetetrazole (PTZ). Furthermore, Peperomia tetraphylla has no influence on spontaneous loco motor activity in mice. The data obtained suggest that Peperomia tetraphylla have mild to moderate anticonvulsant property and may be due to involvement of GABA. Further experimentation is needed to explore the mechanism of this herb as anticonvulsant agent. With this regards herbal anticonvulsants that are successfully exploited are reviewed as under this study.