Development of New Spectrophotometric Methods for the Determination of Perindopril in Pharmaceutical Dosage Forms

International Journal of Novel Trends in Pharmaceutical Sciences,2012,2,1,32-34.
Published:February 2012
Type:Research Article
Author(s) affiliations:

CH.V. Suresh1,*, G. Vidya Sagar2

1Deparment of Biotechnology, Acharya Nagarjuna university, Nagarjuna Nagar, Guntur, Andhra Pradesh, India.

2Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, Gujarat, India.


Three simple and sensitive Spectrophotometric methods have been developed for the determination of Perindopril (PDL) in pure and pharmaceutical dosage forms. Method A is based on the formation of Ion-assosiation complex of the drug with Bromothymol Blue (lmax: 415 nm). Method B is based on the formation of charge transfer complex of the drug with chloranilic acid (lmax: 580 nm). Method C is based on oxidation of the drug under alkaline conditions by oxidizing agents like potassium permanganate and subsequent formation of cherry red colored chromogen (lmax : 609 nm). These methods have been statistically evaluated and found to be precise and accurate.

In-page image(s): 

Optical characteristics, Precision and Accuracy of the proposed methods